Spree-Neiße is a Kreis (district) in the southern part of Brandenburg, Germany. Area 1662 km², population 152,600 (2000). The district's capital is Forst[?].
The district is located in the region of Lusatia. The Spree river runs through the district, while the Neisse river forms the eastern border, which is at the same time the border of Poland. The city of Cottbus is enclosed by, but not part of the district.
Towns in the district: Forst[?], Guben[?], Spremberg[?], Drebkau[?].